A stepwise mechanism for the permeation of phloretin through a lipid bilayer.
نویسندگان
چکیده
منابع مشابه
A stepwise mechanism for the permeation of phloretin through a lipid bilayer
The thermodynamics of interactions between phloretin and a phosphatidylcholine (PC) vesicle membrane are characterized using equilibrium spectrophotometric titration, stopped-flow, and temperature-jump techniques. Binding of phloretin to a PC vesicle membrane is diffusion limited, with an association rate constant greater than 10(8) M-1s-1, and an interfacial activation free energy of less than...
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The transmembrane diffusion of phloretin across planar bilayer lipid membranes is studied under steady-state conditions. Diffusion restrictions and adsorption related effects are measured independently. The adsorption of aligned phloretin dipoles generates a change in the intrinsic dipole potential difference between the inner and outer leaflets of the lipid bilayer. It is monitored by capaciti...
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Phloretin-induced changes in ion transport across lipid bilayer membranes
Phloretin, the aglucone derivative of phlorizin, increases cation conductance and decreases anion conductance in lipid bilayer membranes. In this paper we present evidence that phloretin acts almost exclusively by altering the permeability of the membrane interior and not by modifying the partition of the permanent species between the membrane and the bulk aqueous phases. We base our conclusion...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1982
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.80.4.557